Kp is defined as Ct/Cv. If Kp > 1, what does this indicate about drug distribution?

Kp is defined as Ct/Cv. If Kp > 1, what does this indicate about drug distribution?

• A. More drug in plasma than in tissue.
• B. More drug in tissue than in plasma.
• C. Equal distribution between tissue and plasma.
• D. No distribution occurs.

Answer: (B)

Kp is the tissue-to-plasma distribution ratio, Ct/Cv, showing how a drug partitions between tissues and plasma at equilibrium. When Kp is greater than one, the tissue concentration exceeds the plasma concentration, so the drug preferentially distributes into tissues. This reflects factors like high lipophilicity or strong tissue binding that pull the drug into tissue compartments. In short, there is more drug in tissue than in plasma.

Kp is the tissue-to-plasma distribution ratio, Ct/Cv, showing how a drug partitions between tissues and plasma at equilibrium. When Kp is greater than one, the tissue concentration exceeds the plasma concentration, so the drug preferentially distributes into tissues. This reflects factors like high lipophilicity or strong tissue binding that pull the drug into tissue compartments. In short, there is more drug in tissue than in plasma.